A relic called the Blood Gem, which is said to contain mystical energies, has been delivered to Horizon High after being found at an ancient dig site. While studying the Blood Gem, Gwen tries to contact Peter, who has not been answering her calls. However, the relic is stolen by Scorpion on Tinkerer’s behalf as part of a plot to enhance Scorpion. Gwen’s dormant spider-powers are reawakened by the Blood Gem-powered gun that Tinkerer made. Adopting the alias Ghost-Spider, Gwen works together with Miles and Spider-Girl to take out Scorpion and Tinkerer, who plan to draw Spider-Man out.